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  • A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
    Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP.
    Circulation. 2024 Jan 8. doi: 10.1161/CIRCULATIONAHA.123.066804. Online ahead of print. PMID: 38189150
  • An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.
    Yamaguchi N, Chang EW, Lin Z, Shekhar A, Bu L, Khodadadi-Jamayran A, Tsirigos A, Cen Y, Phoon CKL, Moskowitz IP, Park DS.
    Circulation. 2023 Nov 21;148(21):1705-1722. doi: 10.1161/CIRCULATIONAHA.123.065700. Epub 2023 Sep 29. PMID: 37772400
  • Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
    Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, Lu F, Keating EM, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Hill LD, Kyoung Song M, Trembley MA, Wang P, Gianeselli M, Prondzynski M, Bortolin RH, Bezzerides VJ, Chen K, Seidman JG, Seidman CE, Moskowitz IP, Pu WT.
    Nat Cardiovasc Res. 2023 Oct;2(10):881-898. doi: 10.1038/s44161-023-00334-7. Epub 2023 Oct 12. PMID: 38344303
  • Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice.
    En A, Bogireddi H, Thomas B, Stutzman A, Ikegami S, LaForest B, Almakki O, Pytel P, Moskowitz IP, Ikegami K.
    bioRxiv [Preprint]. 2023 Aug 28:2023.08.28.555134. doi: 10.1101/2023.08.28.555134. PMID: 37693381
  • Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation.
    Selewa A, Luo K, Wasney M, Smith L, Sun X, Tang C, Eckart H, Moskowitz IP, Basu A, He X, Pott S.
    Nat Commun . 2023 Aug 17;14(1):4999. doi: 10.1038/s41467-023-40505-5. PMID: 37591828
  • ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
    Steimle JD, Kim C, Rowton M, Nadadur RD, Wang Z, Stocker M, Hoffmann AD, Hanson E, Kweon J, Sinha T, Choi K, Black BL, Cunningham JM, Moskowitz IP, Ikegami K.
    Cell Rep. 2023 Jun 27;42(6):112665. doi: 10.1016/j.celrep.2023.112665. Epub 2023 Jun 17. PMID: 37330911
  • Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.
    Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP.
    Dev Dyn. 2023 Apr;252(4):483-494. doi: 10.1002/dvdy.555. Epub 2022 Dec 19. PMID: 36495293
  • Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
    Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Steimle JD, Brown JD, Salem JE, Campbell CC, Hong CC, Wells QS, Johnson AN, Short L, Blair MA, Behr ER, Petropoulou E, Jamshidi Y, Benson MD, Keyes MJ, Ngo D, Vasan RS, Yang Q, Gerszten RE, Shaffer C, Parikh S, Sheng Q, Kannankeril PJ, Moskowitz IP, York JD, Wang TJ, Knollmann BC, Roden DM.
    Circulation. 2023 Mar 7;147(10):824-840. doi: 10.1161/CIRCULATIONAHA.122.062193. Epub 2022 Dec 16. PMID: 36524479
  • Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
    Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP.
    Dev Cell. 2022 Sep 26;57(18):2181-2203.e9. doi: 10.1016/j.devcel.2022.08.009. Epub 2022 Sep 14. PMID: 36108627
  • Differential Etv2 threshold requirement for endothelial and erythropoietic development.
    Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BL.
    Cell Rep. 2022 May 31;39(9):110881. doi: 10.1016/j.celrep.2022.110881. PMID: 35649376
  • Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.
    Yang XH, Goldstein A, Sun Y, Wang Z, Wei M, Moskowitz IP, Cunningham JM.
    Nucleic Acids Res. 2022 May 30:gkac452. doi: 10.1093/nar/gkac452. PMID: 35640613
  • Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
    Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD.
    J Clin Invest. 2021 Nov 1;131(21):e144833. doi: 10.1172/JCI144833. PMID: 34491912
  • Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
    Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM.
    Elife. 2021 Oct 13;10:e69288. doi: 10.7554/eLife.69288. PMID: 34643182
  • Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
    Trevino CE, Holleman AM, Corbitt H, Maslen CL, Rosser TC, Cutler DJ, Johnston HR, Rambo-Martin BL, Oberoi J, Dooley KJ, Capone GT, Reeves RH, Cordell HJ, Keavney BD, Agopian AJ, Goldmuntz E, Gruber PJ, O'Brien JE Jr, Bittel DC, Wadhwa L, Cua CL, Moskowitz IP, Mulle JG, Epstein MP, Sherman SL, Zwick ME.
    Sci Rep. 2020 Oct 22;10(1):18051. doi: 10.1038/s41598-020-74650-4. PMID: 33093519
  • Control of cardiomyocyte differentiation timing by intercellular signaling pathways.
    Rowton M, Guzzetta A, Rydeen AB, Moskowitz IP.
    Semin Cell Dev Biol. 2021 Oct;118:94-106. doi: 10.1016/j.semcdb.2021.06.002. Epub 2021 Jun 16. PMID: 34144893
  • Chamber-specific transcriptional responses in atrial fibrillation.
    Lipovsky CE, Jimenez J, Guo Q, Li G, Yin T, Hicks SC, Bhatnagar S, Takahashi K, Zhang DM, Brumback BD, Goldsztejn U, Nadadur RD, Perez-Cervantez C, Moskowitz IP, Liu S, Zhang B, Rentschler SL.
    JCI Insight. 2020 Sep 17;5(18):e135319. doi: 10.1172/jci.insight.135319. PMID: 32841220
  • Transcriptional Patterning of the Ventricular Cardiac Conduction System.
    Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko NB, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP.
    Circ Res. 2020 Jul 17;127(3):e94-e106. doi: 10.1161/CIRCRESAHA.118.314460. Epub 2020 Apr 15. PMID: 32290757
  • Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation
    Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP.
    Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15712-15723. doi: 10.1073/pnas.1914167117. Epub 2020 Jun 19. PMID: 32561646
  • ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
    Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR.
    Circ Res. 2020 Jul 3;127(2):e28-e43. doi: 10.1161/CIRCRESAHA.119.316415. Epub 2020 Apr 29. PMID: 32347164
  • Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.
    van Ouwerkerk AF, Hall AW, Kadow ZA, Lazarevic S, Reyat JS, Tucker NR, Nadadur RD, Bosada FM, Bianchi V, Ellinor PT, Fabritz L, Martin JF, de Laat W, Kirchhof P, Moskowitz IP, Christoffels VM.
    Circ Res. 2020 Jun 19;127(1):34-50. doi: 10.1161/CIRCRESAHA.120.316574. Epub 2020 Jun 18. PMID: 32717170
  • Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.
    Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP.
    Dev Cell. 2020 Mar 23;52(6):699-713.e11. doi: 10.1016/j.devcel.2020.02.011. PMID: 32208162
  • Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq
    Sun X, Wang Z, Hall JM, Perez-Cervantes C, Ruthenburg AJ, Moskowitz IP, Gribskov M, Yang XH.
    PLoS Comput Biol. 2020 Feb 10;16(2):e1007119. doi: 10.1371/journal.pcbi.1007119. eCollection 2020 Feb. PMID: 32040509
  • Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
    Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IP.
    Development. 2020 Feb 5;147(3):dev184432. doi: 10.1242/dev.184432. PMID: 31915147
  • Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.
    Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IP.
    J Clin Invest. 2019 Nov 1;129(11):4937-4950. doi: 10.1172/JCI124231. PMID: 31609246
  • Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
    Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie L.
    PLoS Genet. 2019 May 23;15(5):e1007711. doi: 10.1371/journal.pgen.1007711. eCollection 2019 May. PMID: 31120883
  • A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
    Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR.
    Elife. 2019 Mar 21;8:e41814. doi: 10.7554/eLife.41814. PMID: 30896405
  • Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
    Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y.
    Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11349-E11358. doi: 10.1073/pnas.1810568115. Epub 2018 Nov 14. PMID: 30429326
  • Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.
    Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP.
    Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10615-E10624. doi: 10.1073/pnas.1811624115. Epub 2018 Oct 23. PMID: 30352852
  • A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.
    Singh BN, Koyano-Nakagawa N, Gong W, Moskowitz IP, Weaver CV, Braunlin E, Das S, van Berlo JH, Garry MG, Garry DJ.
    Nat Commun. 2018 Oct 12;9(1):4237. doi: 10.1038/s41467-018-06617-z. PMID: 30315164
  • A promoter interaction map for cardiovascular disease genetics.
    Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA.
    Elife. 2018 Jul 10;7:e35788. doi: 10.7554/eLife.35788. PMID: 29988018
  • Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.
    Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ.
    Circ Genom Precis Med. 2018 Apr;11(4):e002178. doi: 10.1161/CIRCGEN.118.002178. PMID: 29654098
  • Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
    Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP.
    Elife. 2017 Dec 27;6. pii: e31683. doi: 10.7554/eLife.31683. PubMed PMID: 29280435.
  • Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.
    Werner MS, Sullivan MA, Shah RN, Nadadur RD, Grzybowski AT, Galat V, Moskowitz IP, Ruthenburg AJ.
    Nat Struct Mol Biol. 2017 Jul;24(7):596-603. doi: 10.1038/nsmb.3424. Epub 2017 Jun 19. PMID: 28628087
  • Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.
    Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie L.
    Proc Natl Acad Sci USA. 2017 Feb 21;114(8):E1422-E1431. doi:10.1073/pnas.1605137114. Epub 2017 Feb 6. PubMed PMID: 28167794.
  • TBX5: A Key Regulator of Heart Development.
    Steimle JD, Moskowitz IP.
    Curr Top Dev Biol. 2017;122:195-221. doi: 10.1016/bs.ctdb.2016.08.008. PubMed PMID: 28057264.
  • Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
    Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP.
    Sci Transl Med. 2016 Aug 31;8(354):354ra115. doi: 10.1126/scitranslmed.aaf4891. PubMed PMID: 27582060.
  • Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
    Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP.
    Hum Mol Genet. 2016 Jul 15;25(14):3011-3028. PubMed PMID: 27340223; PubMed Central PMCID: PMC5181596.
  • Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
    Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP.
    PLoS Genet. 2014 Oct 30;10(10):e1004604. doi: 10.1371/journal.pgen.1004604. Erratum in: PLoS Genet. 2016 Dec 29;12 (12 ):e1006533. PubMed PMID: 25356765; PubMed Central PMCID: PMC4214600.
  • A common genetic variant within SCN10A modulates cardiac SCN5A expression.
    Van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP.
    J Clin Invest. 2014. 124(4):1844-52. doi: 10.1172/JCI73140. PubMed PMID: 24642470; PubMed Central PMCID: PMC3973109.

    Commentary by David Park and Glenn Fishman:
  • Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
    Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP.
    Dev Cell. 2012 Aug 14;23(2):280-91. doi:10.1016/j.devcel.2012.06.006.
  • TBX5 drives Scn5a expression to regulate cardiac conduction system function.
    Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP.
    J Clin Invest. 2012 Jul 2;122(7):2509-18. doi:10.1172/JCI62617. Epub 2012.
  • A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.
    Friedland-Little JM, Hoffmann AD, Ocbina PJ, Peterson MA, Bosman JD, Chen Y,Cheng SY, Anderson KV, Moskowitz IP.
    Hum Mol Genet.doi: 10.1093/hmg/ddr241.2011 Jun 8.
  • The emerging genetic landscape underlying cardiac conduction system function. Birth Defects Res A Clin Mol Teratol.
    Arnolds DE, Chu A, McNally EM, Nobrega MA, Moskowitz IP.
    2011 Jun;91(6):578-85. doi:10.1002/bdra.20800. Epub 2011 Apr 28.
  • Inducible recombination in the cardiac conduction system of mink:CreERT(2) BAC transgenic mice.
    Arnolds DE, Moskowitz IP.
    Genesis. 2011 Apr 18. doi:10.1002/dvg.20759. [Epub ahead of print]
  • Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development.
    Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE.
    [corrected]. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4006-11. Epub 2011 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5921.
  • Genome-wide identification of mouse congenital heart disease loci.
    Kamp A, Peterson MA, Svenson KL, Bjork BC, Hentges KE, Rajapaksha TW, Moran J, Justice MJ, Seidman JG, Seidman CE, Moskowitz IP, Beier DR.
    Hum Mol Genet. 2010 Aug 15;19(16):3105-13.
  • Sonic hedgehog is required in pulmonary endoderm for atrial septation.
    Hoffmann AD, Peterson MA, Friedland-Little JM, Anderson SA, Moskowitz IP.
    Development. 2009 May;136(10):1761-70.
  • A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
    Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE.
    Cell. 2007 Jun 29;129(7):1365-76.
  • De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
    Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA.
    PLoS Genet. 2016 Apr 8;12(4):e1005963. doi: 10.1371/journal.pgen.1005963. PubMed PMID: 27058611; PubMed Central PMCID: PMC4825975.
  • The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
    Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FL.
    Dev Cell. 2016 Feb 8;36(3):262-75. doi: 10.1016/j.devcel.2016.01.009. PubMed PMID: 26859351; PubMed Central PMCID: PMC4920128.
  • Many ways to break a heart.
    Rowton M, Moskowitz IP.
    Elife. 2015 Aug 25;4. doi: 10.7554/eLife.10040. PubMed PMID: 26305497; PubMed Central PMCID: PMC4548206.
  • The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
    Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RH.
    BMC Dev Biol. 2015 Jul 25;15:30. doi: 10.1186/s12861-015-0080-y. PubMed PMID: 26208718; PubMed Central PMCID: PMC4514943.
  • Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
    Shamis Y, Cullen DE, Liu L, Yang G, Ng SF, Xiao L, Bell FT, Ray C, Takikawa S, Moskowitz IP, Cai CL, Yang X, Li X.
    Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2020-9. doi: 10.1073/pnas.1415541112. PubMed PMID: 25848000; PubMed Central PMCID: PMC4413352.
  • MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
    Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RL.
    Hum Mol Genet. 2015 Apr 15;24(8):2375-89. doi: 10.1093/hmg/ddv004. PubMed PMID: 25574029; PubMed Central PMCID: PMC4380077.
  • Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.
    Smemo S, Campos LC, Moskowitz IP, Krieger JE, Pereira AC, Nobrega MA.
    Hum Mol Genet. 2012 Jul 15;21(14):3255-63. Epub 2012 Apr 27.
  • Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
    Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J.
    J Mol Cell Cardiol. 2012 Mar;52(3):638-49. Epub 2011 Dec 1.
  • Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
    Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J.
    PLoS One. 2011;6(6):e20803. Epub 2011 Jun 3.
  • Complex interactions between genes controlling trafficking in primary cilia.
    Ocbina PJ, Eggenschwiler JT, Moskowitz I, Anderson KV.
    Nat Genet. 2011 Jun;43(6):547-53.
  • Defective sumoylation pathway directs congenital heart disease.
    Wang J, Chen L, Wen S, Zhu H, Yu W, Moskowitz IP, Shaw GM, Finnell RH, Schwartz RJ.
    Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):468-76. doi:10.1002/bdra.20816.
  • DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
    Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LA.
    Cancer Res. 2010 Jul 15;70(14):5840-50.
  • Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
    Pytel P, Husain A, Moskowitz I, Raman J, MacLeod H, Anderson AS, Burke M, McNally EM.
    Cardiovasc Pathol. 2010 Mar-Apr;19(2):e33-6. Epub 2008 Nov 21.
  • Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.
    Dellefave LM, Pytel P, Mewborn S, Mora B, Guris DL, Fedson S, Waggoner D, Moskowitz I, McNally EM.
    Circ Cardiovasc Genet. 2009 Oct;2(5):442-9.
  • A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
    Boles MK, Wilkinson BM, Maxwell A, Lai L, Mills AA, Nishijima I, Salinger AP, Moskowitz I, Hirschi KK, Liu B, Bradley A, Justice MJ.
    BMC Genet. 2009 Mar 6;10:12.
  • E2F3 plays an essential role in cardiac development and function.
    King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA.
    Cell Cycle. 2008 Dec;7(23):3775-80.
  • The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
    Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG.
    PLoS One. 2008 Jul 9;3(7):e2642.
  • Characterization of sinoatrial node in four conduction system marker mice.
    Viswanathan S, Burch JB, Fishman GI, Moskowitz IP, Benson DW.
    J Mol Cell Cardiol. 2007 May;42(5):946-53.
  • Complex genomic rearrangement in CCS-LacZ transgenic mice.
    Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI.
    Genesis. 2007 Feb;45(2):76-82.